Michael J. Large

ORCID: 0000-0002-0170-3918 · 5 papers in corpus · active 2010-2014

Study types

  • article 2
  • book-chapter 1
  • other 1
  • review 1

Condition tags

  • infertility 3
  • endometriosis 2
  • mesh:D004715 1
  • adenomyosis 1
book-chapter 2014
Human Oviduct and Endometrium
·doi:10.1016/b978-0-12-397175-3.00024-7
other 2014
The epidermal growth factor receptor critically regulates endometrial function during early pregnancy
PLoS genetics ·doi:10.1371/journal.pgen.1004451

Infertility and adverse gynecological outcomes such as preeclampsia and miscarriage represent significant female reproductive health concerns. The spatiotemporal expression of growth factors indicates that they play an important role in pre…

article 2013
COUP-TFII Regulates Human Endometrial Stromal Genes Involved in Inflammation
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2013-1191

Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII; NR2F2) is an orphan nuclear receptor involved in cell-fate specification, organogenesis, angiogenesis, and metabolism. Ablation of COUP-TFII in the mouse uterus causes …

review 2012
The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2011.07.027

During the early stages of pregnancy, fertilized embryos must attach to the uterine epithelium, invade into the underlying uterine stroma, and the stroma must then differentiate in a process termed decidualization in order for a successful …

article 2010
Abstract B23: Dominant stablized ß-catenin induces adenomyosis formation and ablation of Mig-6 accelerates progress of adenomyosis formation
·doi:10.1158/1078-0432.tcmusa10-b23

Abstract Adenomyosis is a common gynecological disorder defined by the presence of endometrial glands and stroma within the myometrium. Despite its frequent occurrence, the precise etiology of adenomyosis is still unknown, although it has o…