Aye Aye Khine — Endo Lab

lab-animal 2026

Ovulation-derived extracellular vesicles exhibit sustained oncogenic influence on the exposed fallopian tube fimbrial cells after drainage into peritoneal cavity

Tissue & cell ·doi:10.1016/j.tice.2026.103327

Ovulation is known to damage fallopian tube epithelial (FTE) cells, promote cellular transformation, and contribute to the development of high-grade serous ovarian carcinoma (HGSC). While ovulatory follicular fluid-derived extracellular ves…

other 2025

A Novel Serum-Based Bioassay for Quantification of Cancer-Associated Transformation Activity: A Case-Control and Animal Study

Diagnostics (Basel, Switzerland) ·doi:10.3390/diagnostics15151975

Background/Objectives: The detection of ovarian cancer remains challenging due to the lack of reliable serum biomarkers that reflect malignant transformation rather than mere tumor presence. We developed a novel biotest using an immortalize…

lab-animal 2025

Ovulation releases G-CSF to induce peritoneal neutrophil influx and netosis, facilitating peritoneal seeding of high-grade serous carcinoma

Neoplasia (New York, N.Y.) ·doi:10.1016/j.neo.2025.101236

INTRODUCTION: High-grade serous ovarian cancer (HGSC), the most lethal subtype of epithelial ovarian cancer (EOC), often originates from serous tubal intraepithelial carcinoma (STIC) and is typically diagnosed at advanced stages. However, t…

lab-animal 2024

Epidermal growth factor receptor ligands enriched in follicular fluid exosomes promote oncogenesis of fallopian tube epithelial cells

Cancer cell international ·doi:10.1186/s12935-024-03614-9

BACKGROUND: Incessant ovulation is the main etiologic factor of ovarian high-grade serous carcinomas (HGSC), which mostly originate from the fallopian tube epithelium (FTE). Receptor tyrosine kinase (RTK) ligands essential for follicle deve…

2022

The double engines and single checkpoint theory of endometriosis

·doi:10.22541/au.164450638.85346134/v1

Endometriosis is a common chronic disease of women characterized by ectopic localization of the endometrial tissue in the peritoneal cavity. The pathogenesis of endometriosis closely resembles that of gynecological cancers in ways of menstr…

review 2022

The Double Engines and Single Checkpoint Theory of Endometriosis

Biomedicines ·doi:10.3390/biomedicines10061403

Endometriosis is a chronic disease characterized by the ectopic localization of the endometrial tissue in the peritoneal cavity. Consequently, it causes local pathological changes and systemic symptoms, affecting at least one in every ten w…