Wang D

BACKGROUND: Ovarian cancer remains one of the deadliest gynecologic malignancies. Poor outcomes largely reflect late diagnosis, marked inter- and intratumoral heterogeneity, and variable treatment response. METHODS: This review summarizes …

BACKGROUND: Mitochondrial dysfunction contributes to poor embryo quality and recurrent assisted reproductive technology (ART) failure. Mitochondrial transplantation (MIT), which involves supplementing oocytes with exogenous mitochondria, ha…

OBJECTIVE: To investigate the effect of cheek acupuncture therapy combined with Chinese herbal medicine on chronic pelvic pain (CPP) in female patients. METHODS: Female patients with CPP treated with cheek acupuncture (CA) and Chinese herb…

Iron-deficiency anemia (IDA) affects nearly one-third of women globally, with heavy menstrual bleeding (HMB) being a significant risk factor among those of reproductive age. Despite the substantial burden of HMB-related IDA, patients often …

BackgroundInfertility affects millions of people worldwide, imposing substantial psychological, economic, and social burdens on patients. Although frozen-thawed embryo transfer (FET) is increasingly used, the live birth rate remains approxi…

Embryo implantation requires coordinated interactions between the embryo and the maternal endometrium. Endometrial organoids (EOs) have emerged as promising in vitro models for studying this process. At present, however, mouse-derived EOs (…

QUESTION: To investigate the impact of autoimmune thyroiditis (AIT) on IVF/ICSI outcomes in patients with polycystic ovary syndrome (PCOS) and chronic endometritis (CE). DESIGN: This retrospective cohort study analyzed 444 oocyte retrieval…

OBJECTIVE: To evaluate the efficacy and safety of LED red light therapy in alleviating primary dysmenorrhea. METHODS: A total of 119 patients with primary dysmenorrhea were enrolled in 2022. The intervention was LED red light therapy admin…

OBJECTIVE: Prediction of the therapeutic efficacy of uterine artery embolization (UAE) for adenomyosis (AM) using an MRI-based radiomics model combined with clinical characteristics. METHODS: A retrospective analysis was conducted on 126 p…

Follicular development is a complex and dynamic biological process involving coordinated interactions among endocrine regulation, cellular metabolism, redox homeostasis, mitochondrial function, and immune signaling. Increasing evidence indi…

3-Nitropropionic acid (3-NPA) is an irreversible inhibitor of succinate dehydrogenase (SDH; mitochondrial complex II) that is widely used to model mitochondrial metabolic stress. Direct reproductive studies now show that 3-NPA can increase …

OBJECTIVE: This study aimed to elucidate the functional role and regulating mechanism of Total Glucosides of Paeony (TGP) in chronic endometritis (CE). METHODS: To assess the impact of TGP on CE, a CE rat model was established via infusion…

Poly(lactic acid-lactic acid) (PLGA) has demonstrated significant application potential in tumor-targeted drug delivery systems due to its excellent biocompatibility, degradability, and multifunctionality for loading various therapeutic age…

Following the initial treatment of nasopharyngeal carcinoma (NPC), tumor progression often portends an adverse prognosis for these patients. MicroRNAs (miRNAs) have emerged as critical regulators of tumor immunity, yet their intricate mecha…

In 1995, Morris first described cesarean scar defect as an "isthmocele" by macroscopy following hysterectomy in women with prior cesarean delivery. Cesarean scar defect is associated with gynecological symptoms such as abnormal uterine blee…

Endometriosis (EMs) is a chronic disease affecting millions of women worldwide, yet its pathogenesis remains unclear, and current diagnostic methods are limited. This study based on the EMs dataset from Gene Expression Omnibus (GEO), key ge…

BACKGROUND: Assessing plasma volume is important in the management and treatment of severe acute pancreatitis (SAP). Although it is an easy and rapid method for estimating the plasma volume, the association between estimated plasma volume s…

BACKGROUND: Composite dietary antioxidant index (CDAI) has been found protective to women's health. However, the association between CDAI level and the risk of endometriosis in women is unclear. METHODS: A total of 4,153 women from the Nat…

OBJECTIVES: Per- and polyfluoroalkyl substances (PFAS) have been associated with polycystic ovarian syndrome (PCOS), however, the evidence is limited. This study aimed to explore the associations between PFAS in the follicular fluid and PCO…

The incidence of urothelial carcinoma (UC) ranks second among all urological cancers, accounting for over 90% of malignant tumors in bladder. Patients diagnosed with UC experience a lower quality of life due to rapid progression of the dise…

Endometriosis is an estrogen dependent disease, which is related to infertility. Decidualization is a prerequisite for successful implantation of human embryos, and endometriosis affects the occurrence of decidualization. However, the mecha…

BACKGROUND: In clinical practice, borderline seromucinous ovarian tumor (SMBT) is hard to differentiate preoperatively on ultrasound. CASE: We presented a case of SMBT. In this case, microvascular imaging, particularly three-dimensional (3…

BACKGROUND: As the precursor malignancy of endometrial cancer (EC), about 50% of endometrial complex atypical hyperplasia (CAH) will eventually progress to EC. Elucidating the underlying transformation mechanisms could aid in disease manage…

OBJECTIVE: Clear cell borderline ovarian tumor is a rare subtype of borderline ovarian tumor for which the clinicopathological characteristics, management, and prognosis remain unclear. Herein, we describe the clinical features, treatment o…

BACKGROUND: Endometrial hepatoid adenocarcinoma (HAC) is an exceedingly rare tumor. Histologically, the tumor is predominantly characterized by HAC with additional components, as documented in previous reports. The coexistence of endometria…