Jian‐Min Chen — Endo Lab

article 2020

Effects of gene polymorphism and serum levels of IL-2 and IL-6 on endometriosis.

European review for medical and pharmacological sciences ·doi:10.26355/eurrev_202005_21148

OBJECTIVE: EMT is closely related to gene polymorphism and the expression level of immune-related substances in patients. Therefore, the aim of this study was to investigate the relationship between single nucleotide polymorphism (SNP), as …

2013

Variants in CPA1 are strongly associated with early onset chronic pancreatitis.

Nature genetics ·doi:10.1038/ng.2730

Chronic pancreatitis is an inflammatory disorder of the pancreas. We analyzed CPA1, encoding carboxypeptidase A1, in subjects with nonalcoholic chronic pancreatitis (cases) and controls in a German discovery set and three replication sets. …

2011

Assessing the pathological relevance of SPINK1 promoter variants.

European journal of human genetics : EJHG ·doi:10.1038/ejhg.2011.79

The SPINK1 gene, encoding the human pancreatic secretory trypsin inhibitor, is one of the major genes involved in predisposition to chronic pancreatitis (CP). In this study we have assessed the potential functional impact of 11 SPINK1 promo…

2006

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.

Nature genetics ·doi:10.1038/ng1797

Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1) and the pancreatic secretory trypsin inhibitor (SPINK1) are associated with chronic pancreatitis. Because in…