Keith T. Jones — Endo Lab

2017

DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes.

Development (Cambridge, England) ·doi:10.1242/dev.153965

Mouse oocytes carrying DNA damage arrest in meiosis I, thereby preventing creation of embryos with deleterious mutations. The arrest is dependent on activation of the spindle assembly checkpoint, which results in anaphase-promoting complex …

article 2016

Oocyte maturation arrest in endometriosis is caused by elevated levels of Reactive Oxygen Species and enforced via a DNA Damage Response and the Spindle Assembly Checkpoint pathway

·doi:10.1530/repabs.3.o004

Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)

article 2016

The sensitivity of the DNA damage checkpoint prevents oocyte maturation in endometriosis

Scientific reports ·doi:10.1038/srep36994

Mouse oocytes respond to DNA damage by arresting in meiosis I through activity of the Spindle Assembly Checkpoint (SAC) and DNA Damage Response (DDR) pathways. It is currently not known if DNA damage is the primary trigger for arrest, or if…