Ju TR

No ORCID on file · 2 papers in corpus · active 2022-2023

Study types

  • other 1

Condition tags

  • endometriosis 1
other 2023
Virtual Bioequivalence Assessment of Elagolix Formulations Using Physiologically Based Pharmacokinetic Modeling
The AAPS journal ·doi:10.1208/s12248-023-00794-6

In lieu of large bioequivalence studies and exposing healthy postmenopausal women to additional drug exposure for elagolix coadministered with hormonal add-back therapy, physiologically based pharmacokinetic (PBPK) modeling was used with in…

2022
Physiologically based pharmacokinetic modeling and simulations to inform dissolution specifications and clinical relevance of release rates on elagolix exposure.
Biopharmaceutics & drug disposition ·doi:10.1002/bdd.2315

The aim of this analysis was to use a physiologically based pharmacokinetic (PBPK) model to predict the impact of changes in dissolution rates on elagolix exposures and define clinically relevant acceptance criteria for dissolution. Varying…