John J. Peluso

ORCID: 0000-0003-1263-9242 · 4 papers in corpus
lab-animal 2025
Uterine Pgrmc2 Deficiency Attenuates Endometrial Hyperplasia and Cancer and Prolongs Lifespan in a Pten Loss-of-Function-Induced Cancer Model
Cancers ·doi:10.3390/cancers17071178

The expression of members of the progesterone receptor membrane component (PGRMC) family, particularly PGRMC1, is elevated in diverse types of cancers, particularly those of the female reproductive system. While xenograft tumor studies usin…

lab-animal 2016
Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts
Endocrinology ·doi:10.1210/en.2016-1081

Progesterone (P4) is essential for female fertility. The objective of this study was to evaluate the functional requirement of the nonclassical P4 receptor (PGR), PGR membrane component 1, in regulating female fertility. To achieve this goa…

lab-animal 2016
Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence
Endocrinology ·doi:10.1210/en.2016-1701

The nonclassical progesterone receptors progesterone receptor membrane component (PGRMC) 1 and PGRMC2 have been implicated in regulating cell survival of endometrial and ovarian cells in vitro and are abundantly expressed in these cell type…

lab-animal 2015
Progesterone receptor membrane component 1 deficiency attenuates growth while promoting chemosensitivity of human endometrial xenograft tumors
Cancer letters ·doi:10.1016/j.canlet.2014.09.036

Endometrial cancer is the leading gynecologic cancer in women in the United States with 52,630 women predicted to be diagnosed with the disease in 2014. The objective of this study was to determine if progesterone (P4) receptor membrane com…