Yasuda K — Endo Lab

2025

Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling.

Scientific reports ·doi:10.1038/s41598-025-13102-3

Transformation of cardiac fibroblasts into matrix-producing myofibroblasts plays an important role in tissue repair and fibrosis after myocardial injury. Tcf21 is a basic helix-loop-helix transcription factor that is essential for the devel…

2024

Identification of Prostaglandin I2 Synthase Rare Variants in Patients With Williams Syndrome and Severe Peripheral Pulmonary Stenosis.

Journal of the American Heart Association ·doi:10.1161/jaha.123.032872

BackgroundPeripheral pulmonary stenosis (PPS) is a condition characterized by the narrowing of the pulmonary arteries, which impairs blood flow to the lung. The mechanisms underlying PPS pathogenesis remain unclear. Thus, the aim of this st…

article 2001

The inhibitory effect of dienogest, a synthetic steroid, on the growth of human endometrial stromal cells in vitro

Molecular human reproduction ·doi:10.1093/molehr/7.4.341

Dienogest is a synthetic steroid that has been used as a progestogen in contraceptive pills and is currently being studied for its possible clinical use in the treatment of endometriosis. In this study, we investigated the direct effects of…