Zhang Y

OBJECTIVE: Precision medicine applications depend on elucidating the underlying molecular mechanisms of disease. However, many disorders, such as endometriosis, remain poorly characterised genetically due to data scarcity, positive-unlabell…

Perioperative abstinent smokers experience heightened pain sensitivity and increased postoperative analgesic requirements, likely due to nicotine withdrawal-induced hyperalgesia. However, the underlying neural mechanisms in humans remain un…

PurposeThis study aimed to develop and validate a robust multicenter deep learning pipeline that integrates radiomic descriptors with deep feature embeddings to enable comprehensive ovarian tumor analysis from ultrasound imaging, encompassi…

Adenomyosis involves aberrant inflammation and immune dysregulation in its pathogenesis. This multicenter study investigated the association between the systemic immune inflammation index (SII) and adenomyosis risk among 74,900 participants…

ObjectiveTo explore the factors associated with elevated serum progesterone (P) levels on the day of hCG administration in patients undergoing controlled ovarian stimulation using a gonadotropin-releasing hormone antagonist (GnRH-A) protoco…

OBJECTIVE: There is currently no consensus on the risk factors for recurrent ovarian endometrioma after surgery. This study aimed to identify independent risk factors and develop a clinical nomogram to predict postoperative recurrence. MET…

Endometriosis progression is driven by oxidative stress and excessive angiogenesis within an inflammatory microenvironment. To overcome these challenges, we designed ROS/pH dual-responsive Alpelisib-loaded nanoparticles (Alp@TAT-AT7-NPs) fu…

BackgroundOvarian cancer remains one of the deadliest gynecologic malignancies. Poor outcomes largely reflect late diagnosis, marked inter- and intratumoral heterogeneity, and variable treatment response.MethodsThis review summarizes recent…

BACKGROUND: Deep infiltrating endometriosis (DIE) is a severe subtype of endometriosis, often associated with dysmenorrhea and significant diagnostic challenges. Conventional biomarkers, such as cancer antigen 125 (CA125), lack sufficient s…

Per- and polyfluoroalkyl substances (PFAS) have been previously associated with polycystic ovary syndrome (PCOS). However, the health effects of emerging PFAS alternatives on PCOS remain unclear. This study aims to examine the associations …

BACKGROUND: Smoking and alcohol consumption have been consistently associated with adverse female reproductive outcomes; however, whether these associations reflect causal effects or are mediated by specific circulating metabolites remains …

BACKGROUND: Patients undergoing assisted reproductive technology (ART) frequently manifest sleep disturbances and psychological morbidity. This study examined associations between cerebral activation patterns, sleep quality, and psychologic…

STUDY QUESTION: What is the current landscape of randomized controlled trials (RCTs) evaluating stem cell-based therapies for women's reproductive diseases, and how effectively has preclinical research informed their clinical translation? …

Accurate pre-operative discrimination between ovarian endometriomas (EMs) and other benign ovarian tumors is crucial for surgical planning and fertility counseling. This study aimed to evaluate the diagnostic performance of serum CA125, CA1…

BACKGROUND: Endometriosis (EMs) is a common gynecological disorder associated with infertility. EMs patients often require assisted reproductive technology (ART) but exhibit lower success rates. This study aimed to characterize the follicul…

Endometriosis, affecting approximately 10% of reproductive-aged women worldwide, is widely recognized as a chronic inflammatory disease. Inflammation-related genes (IRGs) play a crucial role in the occurrence and progression of various dise…

Currently available classification criteria for obstetric antiphospholipid syndrome (OAPS) are often overly strict and may miss a considerable number of patients with so-called "non-criteria-defined OAPS". We aimed to establish a diagnostic…

Abstract Objective This study aims to systematically compare the short-term efficacy and safety differences between daily oral 2 mg Dienogest (DNG) and daily oral 10 mg Mifepristone (MIF) in the treatment of patients with symptomatic aden…

BACKGROUND: Endometriosis-associated ovarian cancer is a distinct form of epithelial ovarian cancer that arises from the malignant transformation of benign endometriotic lesions. While epithelial-mesenchymal transition is acknowledged as a …

BACKGROUND: In recent years, microRNAs have attracted increasing attention for their potential diagnostic and prognostic value across various diseases. This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of mi…

Yuru Wang,1,* Zihan Zhu,2,* Xu Jin,3 Zhaoyan Ding,2 Wen Zhong,2 Yueming Zhang,1 Songwei Feng,1,4 Ting Wu1 1Department of Obstetrics and Gynaecology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Rep…

BACKGROUND: Endometriosis is a chronic, estrogen-dependent inflammatory disorder that causes substantial pain and infertility. Observational studies have reported higher rates of multiple psychiatric disorders among individuals with endomet…

PURPOSE: Regarding anesthesia management for high-intensity focused ultrasound (HIFU) treatment of uterine adenomyosis, existing research is limited. While considered non-invasive, HIFU ablation carries risks such as thermal injury to adjac…