Leila Saleh

ORCID: 0000-0002-7604-7871 · 3 papers in corpus
lab-animal 2010
Administration of betaHCG leads to dose-dependent changes of gene expression signature of endometriotic stromal cells
Reproductive BioMedicine Online ·doi:10.1016/j.rbmo.2010.01.010

Preliminary studies have shown that systemic beta-human chorionic gonadotrophin (betaHCG) therapy alleviates endometriosis-related chronic pelvic pain. The underlying mechanism, however, is completely unknown. This study has investigated th…

lab-animal 2007
Effect of highly purified human chorionic gonadotropin preparations on the gene expression signature of stromal cells derived from endometriotic lesions: potential mechanisms for the therapeutic effect of human chorionic gonadotropin in vivo
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.02.006

OBJECTIVE: To investigate alterations in the overall gene expression profile of endometriosis-derived stroma with increasing concentrations of hCG by using the Affymetrix GeneChip U133 Set. DESIGN: In vitro study. SETTING: Academic resear…

lab-animal 2007
Human chorionic gonadotrophin attenuates NF-kappaB activation and cytokine expression of endometriotic stromal cells
Molecular human reproduction ·doi:10.1093/molehr/gam032

Recently, a clinical study provided evidence that treatment of endometriotic women with human chorionic gonadotrophin (hCG) alleviates disease-related pain and sleeplessness suggesting therapeutic effects of the hormone. Since endometriosis…