Alicia A. Walf — Endo Lab

article 2014

Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats

·doi:10.1007/s00213-013-3406-0

RationaleProgesterone and its metabolite, 5α-pregnan-3α-ol-20-one (3α,5α-THP), have actions in the ventral tegmental area (VTA) that are required for lordosis, a characteristic mating posture of female rodents. 17β-estradiol (estradiol) co-…

2009

Nociceptive and anxiety-like behavior in reproductively competent and reproductively senescent middle-aged rats.

Gender medicine ·doi:10.1016/j.genm.2009.03.002

BackgroundChanges in levels of estradiol and progesterone that occur with the transition to reproductive senescence may influence nociception or affect.ObjectiveTo ascertain whether nociceptive and affective processes change with reproducti…

article 2008

Activity of protein kinase C is important for 3α,5α-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats

·doi:10.1016/j.brainresbull.2008.07.002

In the ventral tegmental area, progestogens facilitate sexual receptivity of rodents via actions at dopamine type 1-like and/or gamma-aminobutyric acid type A receptors and activation of downstream signal transduction molecules. In the pres…

article 2006

In the Ventral Tegmental Area, Progestins’ Membrane-Mediated Actions for Lordosis of Hamsters and Rats Involve Protein Kinase A

·doi:10.1159/000100510

Progestin-facilitated lordosis of hamsters and rats is enhanced by activation of dopamine type 1 (D1) or GABAA/benzodiazepine receptor complexes (GBRs) in the ventral tegmental area (VTA) and these effects involve G-proteins and second mess…

article 2004

Progestins' actions in the VTA to facilitate lordosis involve dopamine-like type 1 and 2 receptors

·doi:10.1016/j.pbb.2004.04.014

In the ventral tegmental area (VTA), 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) facilitates lordosis. Whether this involves dopamine type 1 (D1) or dopamine type 2 (D2) receptors is of interest. Ovariectomized (ovx) rats with guide…