Defan Wang

No ORCID on file · 3 papers in corpus
review 2026
Role of Hypoxia-Inducible Factor-1 Alpha in Endometrial Decidualization
·doi:10.3390/biom16101483

Endometrial decidualization is a hormonally programmed differentiation and tissue-remodeling process that prepares the endometrium for embryo implantation and supports early pregnancy. It involves coordinated changes in endometrial stromal …

review 2026
The potential role of NLRP3 inflammasome in integrating redox, metabolic, and inflammatory signals during follicular development: a hypothesis-driven redox-metabolic integrator framework
Frontiers in cell and developmental biology ·doi:10.3389/fcell.2026.1914362

Follicular development is a complex and dynamic biological process involving coordinated interactions among endocrine regulation, cellular metabolism, redox homeostasis, mitochondrial function, and immune signaling. Increasing evidence indi…

review 2026
The Succinate-HIF-1α-NLRP3 Axis in 3-Nitropropionic Acid-Induced Ovarian Dysfunction: A Testable Metabolic-Inflammatory Framework
Biology ·doi:10.3390/biology15171557

3-Nitropropionic acid (3-NPA) is an irreversible inhibitor of succinate dehydrogenase (SDH; mitochondrial complex II) that is widely used to model mitochondrial metabolic stress. Direct reproductive studies now show that 3-NPA can increase …