Tolar J

ORCID: 0000-0002-0957-4380 · 1 paper in corpus

2018

Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect.

JCI insight ·doi:10.1172/jci.insight.96219

NK cell-based immunotherapies have been gaining traction in the clinic for treatment of cancer. IL-15 is currently being used in number of clinical trials to improve NK cell expansion and function. The objective of this study is to evaluate…