Bunnett NW — Endo Lab

2025

Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation.

Nature communications ·doi:10.1038/s41467-025-63782-8

Analgesia by non-steroidal anti-inflammatory drugs (NSAIDs) is ascribed to inhibition of prostaglandin (PG) biosynthesis and ensuing inflammation. However, NSAIDs have life-threatening side effects, and inhibition of inflammation delays pai…

2023

Neuropilin-1 is essential for vascular endothelial growth factor A-mediated increase of sensory neuron activity and development of pain-like behaviors.

Pain ·doi:10.1097/j.pain.0000000000002970

AbstractNeuropilin-1 (NRP-1) is a transmembrane glycoprotein that binds numerous ligands including vascular endothelial growth factor A (VEGFA). Binding of this ligand to NRP-1 and the co-receptor, the tyrosine kinase receptor VEGFR2, elici…

2016

Legumain is activated in macrophages during pancreatitis.

American journal of physiology. Gastrointestinal and liver physiology ·doi:10.1152/ajpgi.00047.2016

Pancreatitis is an inflammatory disease of the pancreas characterized by dysregulated activity of digestive enzymes, necrosis, immune infiltration, and pain. Repeated incidence of pancreatitis is an important risk factor for pancreatic canc…