Lin VCL

ORCID: 0000-0002-7997-2771 · 2 papers in corpus

2026

Ligand-Dependent and -Independent Functions of Activation Function 1 of Progesterone Receptor in Genome-Wide Gene Regulation and in Cell Proliferation and Apoptosis of Breast Cancer Cells.

International journal of molecular sciences ·doi:10.3390/ijms27062916

Progesterone receptor (PR) regulates gene expression through recruiting coregulators and general transcription factors by activation functions AF1 and AF2. AF1 localizes to the non-conserved and disordered N-terminal domain and is believed …

2022

Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus.

BMC biology ·doi:10.1186/s12915-022-01410-3

BackgroundProgesterone receptor (PGR) is a master regulator of uterine function through antagonistic and synergistic interplays with oestrogen receptors. PGR action is primarily mediated by activation functions AF1 and AF2, but their physio…