Kira Weissman

ORCID: 0000-0002-3012-2960 · 1 paper in corpus · active 2021
2021
Successes, surprises and pitfalls in modular polyketide synthase engineering: generation of ring-contracted stambomycins
·doi:10.21203/rs.3.rs-222743/v1

Abstract The modular organization of the type I polyketide synthases (PKSs) would seem propitious for rational engineering of desirable analogous. However, despite decades of efforts, such experiments remain largely inefficient. Here, we c…