Tan W — Endo Lab

2026

The role and underlying mechanism of FABP4 dysregulation mediated by m6A modification in unexplained recurrent spontaneous abortion.

Journal of translational medicine ·doi:10.1186/s12967-026-08118-w

BackgroundUnexplained recurrent spontaneous abortion (URSA) poses a significant clinical challenge with an elusive pathogenesis. FABP4 is crucial for lipid homeostasis and placental development, but its specific role and regulatory mechanis…

2026

Xanthohumol: Mechanistic Actions and Emerging Evidence as a Multi-Target Natural Nutraceutical.

Nutrients ·doi:10.3390/nu18030520

BackgroundXanthohumol (XN), a prenylated chalcone flavonoid derived from hops (Humulus lupulus), is increasingly recognized as a highly pleiotropic natural compound.ObjectiveWe aimed to structure XN's mechanistic hierarchy with emerging tra…

2024

NLRP3 Inflammasome Upregulates PD-L1 in Ovarian Cancer and Contributes to an Immunosuppressive Microenvironment.

ImmunoTargets and therapy ·doi:10.2147/itt.s495564

IntroductionThe NLRP3 inflammasome has been implicated in the initiation of inflammation and tumorigenesis; however, its role in epithelial ovarian cancer (EOC) remains unclear.MethodsThis study employed high-throughput sequencing data, ELI…

2022

Administration of depot GnRH agonist prior to programmed frozen-thawed embryo transfer does not improve the live birth rate in ovulatory women: A large, multi-center retrospective study.

Medicine ·doi:10.1097/md.0000000000030991

Despite that gonadotropin-releasing hormone (GnRH) agonist pretreatment has been widely used before programmed frozen-thawed transfer (FET), its impact on live birth rates in ovulatory women remains uncertain. In the present study, we aim t…

2022

Aptamer Nanomaterials for Ovarian Cancer Target Theranostics.

Frontiers in bioengineering and biotechnology ·doi:10.3389/fbioe.2022.884405

Ovarian cancer is among the leading causes of gynecological cancer-related mortality worldwide. Early and accurate diagnosis and an effective treatment strategy are the two primary means of improving the prognosis of patients with ovarian c…

2022

TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NF-κB signaling pathway.

Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-022-01013-1

BackgroundSuccessful implantation is a complex process that is influenced by embryo quality, endometrial receptivity, immune factors, and the specific type of in vitro fertilization protocol used. DNA topoisomerase IIα (TOP2A) is a well-kno…

2021

Evaluation of GnRH antagonist pretreatment before ovarian stimulation in a GnRH antagonist protocol in normal ovulatory women undergoing IVF/ICSI: a randomized controlled trial.

Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-021-00836-8

BackgroundSynchronization of follicles is key to improving ovulation stimulation with the gonadotropin-releasing hormone (GnRH) antagonist protocol. GnRH antagonist administration in the early follicular phase can quickly decrease gonadotro…

article 2021

The Influence Mechanism of Abnormal Immunophilin FKBP52 on the Expression Levels of PR-A and PR-B in Endometriosis Based on Endometrial Stromal Cell Model in Vitro

Organogenesis ·doi:10.1080/15476278.2020.1860424

As a chaperone protein of progesterone receptor (PR), FK-506 Binding Protein 52 (FKBP52) can enhance the activity of PR, but the mechanism of FKBP52 affecting PR expression levels is difficult to clarify. Here, we report a novel in vitro mo…

2018

Early identification of recurrence in ovarian cancer: a comparison between the ovarian cancer metastasis index and CA-125 levels.

PeerJ ·doi:10.7717/peerj.5912

Ovarian cancer (OC) is the second most common gynecologic malignancy. A clinical observational study was performed to investigate whether indicators that assess the risk of metastasis can identify recurrence earlier in OC patients. By succe…