Md Mesbah Uddin

Germline variation and somatic mutation are intricately connected and together shape human traits and disease risks. Germline variants are present from conception, but they vary between individuals and accumulate over generations. By contra…

Abstract Age-related changes to the epigenome are well-documented, especially the pattern of genome-wide DNA methylation (DNAm) changes observed in blood. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-rel…