Corona RI

No ORCID on file · 4 papers in corpus
2022
chromMAGMA: regulatory element-centric interrogation of risk variants.
Life science alliance ·doi:10.26508/lsa.202201446

Candidate causal risk variants from genome-wide association studies reside almost exclusively in noncoding regions of the genome and innovative approaches are necessary to understand their biological function. Multi-marker analysis of genom…

preprint 2021
A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes
·doi:10.1101/2021.06.28.21259290

Abstract Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Data from large endometriosis and EOC genome-wide association meta-analyses were used to estimate the genetic correlation and evaluate the causal…

other 2021
Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube
Cell reports ·doi:10.1016/j.celrep.2021.108978

The human fallopian tube harbors the cell of origin for the majority of high-grade serous "ovarian" cancers (HGSCs), but its cellular composition, particularly the epithelial component, is poorly characterized. We perform single-cell transc…

2020
Ovarian Cancer Risk Variants Are Enriched in Histotype-Specific Enhancers and Disrupt Transcription Factor Binding Sites.
American journal of human genetics ·doi:10.1016/j.ajhg.2020.08.021

Quantifying the functional effects of complex disease risk variants can provide insights into mechanisms underlying disease biology. Genome-wide association studies have identified 39 regions associated with risk of epithelial ovarian cance…