Slominski AT

ORCID: 0000-0001-8963-3995 · 3 papers in corpus
2020
Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders.
Genes and immunity ·doi:10.1038/s41435-020-0096-6

Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here its side chain is cleaved by CYP11A1 producing pregnenolone.…

2016
Role of the steroidogenic acute regulatory protein in health and disease.
Endocrine ·doi:10.1007/s12020-015-0715-6

Steroid hormones are an important class of regulatory molecules that are synthesized in steroidogenic cells of the adrenal, ovary, testis, placenta, brain, and skin, and influence a spectrum of developmental and physiological processes. The…

2013
Key role of CRF in the skin stress response system.
Endocrine Reviews ·doi:10.1210/er.2012-1092

The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the corresponding receptors (CRFRs 1 and 2), represents a mile…