Vibeke Hougaard Sunesen

No ORCID on file · 2 papers in corpus

article 2005

Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug

·doi:10.1016/j.ejps.2004.11.005

The influence of liquid intake and a lipid-rich meal on the bioavailability of a lipophilic drug was investigated. Danazol was used as the model substance. In a randomized four-way crossover study eight healthy male volunteers received four…

article 2005

In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media

·doi:10.1016/j.ejps.2004.11.007

The purpose of the study was to design dissolution tests that were able to distinguish between the behaviour of danazol under fasted and fed conditions, by using biorelevant media. In vitro dissolution of 100mg danazol capsules was performe…