Zhihua Zhang

No ORCID on file · 3 papers in corpus
other 2026
CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs
EMBO molecular medicine ·doi:10.1038/s44321-026-00448-y

Precise regulation of alternative splicing (AS) of maternal mRNAs is crucial for maintaining mRNA homeostasis and for acquiring oocyte competence. However, the regulatory factors and mechanisms of AS regulating oocyte competence and human f…

observational 2026
Genetic landscape of human oocyte/embryo defects
Cell genomics ·doi:10.1016/j.xgen.2025.101012

Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet…

other 2023
Alteration of relative telomere length and telomerase reverse transcriptase expression in the granulosa cells of women during aging and assessment of in vitro fertilization outcomes
Molecular medicine reports ·doi:10.3892/mmr.2023.13093

Telomere attrition plays a critical role in the reproductive aging process in humans. Telomere length (TL) is typically regulated by telomerase, the main component of which is telomerase reverse transcriptase (TERT). The aim of the present …