Sophie Clarke

No ORCID on file · 2 papers in corpus

observational 2019

Determining the Relationship Between Hot Flushes and LH Pulses in Menopausal Women Using Mathematical Modeling

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2018-02797

BACKGROUND: Hypothalamic kisspeptin/neurokinin B/dynorphin (KNDy) neurones regulate LH pulsatility. It is widely accepted that the menopausal hot flush (HF) consistently synchronizes with the LH pulse, implicating the hypothalamic KNDy neur…

rct 2017

A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial

Human reproduction (Oxford, England) ·doi:10.1093/humrep/dex253

STUDY QUESTION: Can increasing the duration of LH-exposure with a second dose of kisspeptin-54 improve oocyte maturation in women at high risk of ovarian hyperstimulation syndrome (OHSS)? SUMMARY ANSWER: A second dose of kisspeptin-54 at 1…