Han Liang

No ORCID on file · 2 papers in corpus

review 2022

Regulation and physiological functions of phoenixin

Frontiers in molecular biosciences ·doi:10.3389/fmolb.2022.956500

Phoenixin is a newly discovered neuropeptide generated from small integral membrane protein 20. Phoenixin is a ligand for the G protein-coupled receptor 173 (GPR173) and has been detected in central and peripheral tissues of human, rats, mi…

lab-animal 2014

Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors

Cancer cell ·doi:10.1016/j.ccell.2014.08.017

PIK3R1 (p85α regulatory subunit of PI3K) is frequently mutated across cancer lineages. Herein, we demonstrate that the most common recurrent PIK3R1 mutation PIK3R1(R348∗) and a nearby mutation PIK3R1(L370fs), in contrast to wild-type and mu…