Zhaoyang Zhong — Endo Lab

lab-animal 2026

Intestinal microbiota-associated LysoPC(16:0) promotes endometriosis via PPARγ-mediated M2 macrophage polarization and IL-10 secretion

·doi:10.1016/j.isci.2026.117917

Both gut microbiota dysbiosis and altered pelvic immune microenvironment have been linked to endometriosis (EM), but the metabolites connecting the two remain undefined. Combining 16S rDNA sequencing with non-targeted metabolomics in a muri…

lab-animal 2026

Ionomics powered single-cell mapping reveals targetable iron dysregulation in endometriosis associated macrophages

·doi:10.1186/s12916-026-05095-1

Endometriosis affects approximately 10% of women of reproductive age worldwide. Although elemental components of refluxed menstrual blood have been implicated in disease progression, comprehensive ionomic profiling of the endometriotic micr…

lab-animal 2026

Stromal cell-derived itaconate promotes endometriosis via macrophage NRF2 and lysosomal pH modulation

Redox biology ·doi:10.1016/j.redox.2026.104101

Endometriosis (EM) is driven by immune dysregulation and macrophage dysfunction, yet the underlying mechanisms remain unclear. Here, metabolomic profiling revealed excessive itaconate accumulation in EM lesions, primarily due to elevated ci…

lab-animal 2025

Iron overload-induced ferroptosis in CD8+ T cells leads to functional abnormalities that promote endometriosis progression

BMC medicine ·doi:10.1186/s12916-025-04369-4

BACKGROUND: Endometriosis (EM) exhibits localised iron overload. However, the contribution of ferroptosis to EM pathogenesis remains unclear. We investigated how iron overload affects CD8⁺ T cell immune function and the underlying ferroptot…

2025

Stromal cell–macrophage metabolic crosstalk via itaconate promotes immune imbalance in endometriosis

·doi:10.1016/j.jri.2025.104703