Stephen G. Hillier

article 2025

Luteal phase oral dexamethasone administration alters the endometrial steroid milieu

Endocrine connections ·doi:10.1530/ec-24-0638

We previously published the DexFEM trial, which showed that in women with heavy menstrual bleeding (HMB), oral dexamethasone reduces menstrual blood loss. Here, we report a pharmacodynamic analysis exploring the likely mechanism for this ef…

article 2021

Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

·doi:10.1016/j.ebiom.2021.103434

Background: The symptom of heavy menstrual bleeding (HMB) diminishes quality-of-life for many mid-age women and imposes substantial societal burden. We investigated our hypothesis that HMB reflects impaired endometrial vasoconstriction due …

2017

Targeting lysyl oxidase reduces peritoneal fibrosis.

PloS one ·doi:10.1371/journal.pone.0183013

BackgroundAbdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposit…

2015

Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy.

The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2015.03.010

Epithelial ovarian cancer (EOC) accounts for about 90% of malignant ovarian tumors, and estrogen is often implicated in disease progression. We therefore compared the potential for gating of estrogen action via pre-receptor metabolism in no…

article 2011

IL1α and IL4 signalling in human ovarian surface epithelial cells

·doi:10.1530/joe-11-0081

The human ovarian surface epithelium (hOSE) is a mesothelial layer that surrounds the ovary and undergoes injury and repair cycles after ovulation-associated inflammation. We previously showed that IL4 is a key regulator of progesterone bio…

2009

Biological versus chronological ovarian age: implications for assisted reproductive technology.

Reproductive biology and endocrinology : RB&E ·doi:10.1186/1477-7827-7-101

BackgroundWomen have been able to delay childbearing since effective contraception became available in the 1960s. However, fertility decreases with increasing maternal age. A slow but steady decrease in fertility is observed in women aged b…

article 2009

Cortisol Inactivation by 11β-Hydroxysteroid dehydrogenase-2 May Enhance Endometrial Angiogenesis via Reduced Thrombospondin-1 in Heavy Menstruation

·doi:10.1210/jc.2008-1879

CONTEXT: Heavy menstrual bleeding (HMB; menorrhagia) impairs quality of life for women and requires medication or surgery. Because glucocorticoids inhibit angiogenesis in other organs, we hypothesized that endometrium of women with HMB is s…

other 2004

Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis

The Journal of endocrinology ·doi:10.1677/joe.1.05754

The human ovarian surface epithelium (HOSE) is a common site of gynaecological disease including endometriosis and ovarian cancer, probably due to serial injury-repair events associated with successive ovulations. To comprehend the importan…

article 1988

The effects of clomiphene citrate on the histology of human endometrium in regularly cycling women undergoing in vitro fertilization

·doi:10.1016/s0015-0282(16)59719-2

Thirty-six women with histories of regular cycles undergoing elective laparoscopic sterilization volunteered to participate in a research program of endometrial biopsy, oocyte donation, and in vitro fertilization (IVF). One half of the volu…