Stephen G. Hillier

ORCID: 0000-0001-7378-5855 · 5 papers in corpus · active 1988-2025

Study types

  • article 5
article 2025
Luteal phase oral dexamethasone administration alters the endometrial steroid milieu
·doi:10.1530/ec-24-0638

We previously published the DexFEM trial, which showed that in women with heavy menstrual bleeding (HMB), oral dexamethasone reduces menstrual blood loss. Here, we report a pharmacodynamic analysis exploring the likely mechanism for this ef…

article 2021
Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)
·doi:10.1016/j.ebiom.2021.103434

Background: The symptom of heavy menstrual bleeding (HMB) diminishes quality-of-life for many mid-age women and imposes substantial societal burden. We investigated our hypothesis that HMB reflects impaired endometrial vasoconstriction due …

article 2011
IL1α and IL4 signalling in human ovarian surface epithelial cells
·doi:10.1530/joe-11-0081

The human ovarian surface epithelium (hOSE) is a mesothelial layer that surrounds the ovary and undergoes injury and repair cycles after ovulation-associated inflammation. We previously showed that IL4 is a key regulator of progesterone bio…

article 2009
Cortisol Inactivation by 11β-Hydroxysteroid dehydrogenase-2 May Enhance Endometrial Angiogenesis via Reduced Thrombospondin-1 in Heavy Menstruation
·doi:10.1210/jc.2008-1879

CONTEXT: Heavy menstrual bleeding (HMB; menorrhagia) impairs quality of life for women and requires medication or surgery. Because glucocorticoids inhibit angiogenesis in other organs, we hypothesized that endometrium of women with HMB is s…

article 1988
The effects of clomiphene citrate on the histology of human endometrium in regularly cycling women undergoing in vitro fertilization
·doi:10.1016/s0015-0282(16)59719-2