Lin‐Yu Chen — Endo Lab

2023

Cervical Secretion Methylation Is Associated with the Pregnancy Outcome of Frozen-Thawed Embryo Transfer.

International journal of molecular sciences ·doi:10.3390/ijms24021726

The causes of implantation failure remain a black box in reproductive medicine. The exact mechanism behind the regulation of endometrial receptivity is still unknown. Epigenetic modifications influence gene expression patterns and may alter…

2023

DNA Methylation of Window of Implantation Genes in Cervical Secretions Predicts Ongoing Pregnancy in Infertility Treatment.

International journal of molecular sciences ·doi:10.3390/ijms24065598

Window of implantation (WOI) genes have been comprehensively identified at the single cell level. DNA methylation changes in cervical secretions are associated with in vitro fertilization embryo transfer (IVF-ET) outcomes. Using a machine l…

2022

Endometrial Cancer Detection Using a Cervical DNA Methylation Assay (MPap) in Women with Abnormal Uterine Bleeding: A Multicenter Hospital-Based Validation Study.

Cancers ·doi:10.3390/cancers14174343

BackgroundWe describe a DNA methylation assay, named MPap test, using cervical scraping as an alternative technique for endometrial cancer detection.MethodsA multicenter hospital-based, two-stage validation study was conducted to validate t…

article 2022

Epigenomic Analysis Reveals the KCNK9 Potassium Channel as a Potential Therapeutic Target for Adenomyosis

International journal of molecular sciences ·doi:10.3390/ijms23115973

Adenomyosis is linked to dysmenorrhea and infertility. The pathogenesis of adenomyosis remains unclear, and little is known of the genetic and epigenetic changes in the eutopic endometrium in adenomyosis, which may predispose patients to th…