John A. Mackintosh

ORCID: 0000-0002-5254-4144 · 3 papers in corpus · active 2020-2025

Study types

  • article 3
article 2025
Efficacy and Safety of Danazol in Pulmonary Fibrosis Associated With Short Telomeres: A Phase 2 Randomized Clinical Trial
·doi:10.1164/ajrccm.2025.211.abstracts.a1010

Abstract RATIONALE: Telomere attrition is identified in a significant number of patients with pulmonary fibrosis (PF) and is predictive of worse survival. Danazol, a synthetic sex hormone, has shown promise in telomere biology disorders but…

article 2021
TELO-SCOPE study: a randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis
·doi:10.1136/bmjresp-2021-001127

INTRODUCTION: Recent discoveries have identified shortened telomeres and related mutations in people with pulmonary fibrosis (PF). There is evidence to suggest that androgens, including danazol, may be effective in lengthening telomeres in …

article 2020
Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol
·doi:10.1002/rcr2.607

We report the case of a 42-year-old female with a history of finger clubbing which improved during pregnancy, a history of unexplained hepatosplenomegaly, and subsequent non-specific interstitial pneumonia with respiratory failure. Given a …