Eric R. Gross — Endo Lab

2021

TRP Channels as Sensors of Aldehyde and Oxidative Stress.

Biomolecules ·doi:10.3390/biom11101401

The transient receptor potential (TRP) cation channel superfamily comprises more than 50 channels that play crucial roles in physiological processes. TRP channels are responsive to several exogenous and endogenous biomolecules, with aldehyd…

article 2020

Aberrant reactive aldehyde detoxification by aldehyde dehydrogenase-2 influences endometriosis development and pain-associated behaviors

Pain ·doi:10.1097/j.pain.0000000000001949

Endometriosis affects ∼176 million women worldwide, yet on average, women experience pain ∼10 years from symptom onset before being properly diagnosed. Standard treatments (drugs or surgery) often fail to provide long-term pain relief. Elev…

article 2018

Endometriosis‐associated vaginal hyperalgesia is mediated by the balance of reactive aldehyde production and metabolism.

·doi:10.1096/fasebj.2018.32.1_supplement.684.4

Background Endometriosis affects ~176 million women worldwide and is characterized by the growth of endometrial tissue outside the uterus (known as endometrial ectopic cysts). How endometriosis becomes associated with painful symptoms is no…

other 2016

Prostaglandin levels, vaginal innervation, and cyst innervation as peripheral contributors to endometriosis-associated vaginal hyperalgesia in rodents

Molecular and cellular endocrinology ·doi:10.1016/j.mce.2016.08.017

Endometriosis is a painful condition characterized by growth of endometrial cysts outside the uterus. Here, we tested the hypothesis that peripheral innervation and prostaglandin levels contribute to endometriosis-associated pain. Female Sp…