Halle MK — Endo Lab

2014

Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.

Human genetics ·doi:10.1007/s00439-013-1383-3

Epithelial ovarian cancer (EOC) is a heterogeneous cancer with both genetic and environmental risk factors. Variants influencing the risk of developing the less-common EOC subtypes have not been fully investigated. We performed a genome-wid…

other 2014

Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10

Cancer research ·doi:10.1158/0008-5472.CAN-13-1051

A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (rs17561). Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly unde…

2013

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.

Nature communications ·doi:10.1038/ncomms2629

HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovaria…

2013

Polymorphisms in inflammation pathway genes and endometrial cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology ·doi:10.1158/1055-9965.epi-12-0903

BackgroundExperimental and epidemiologic evidence have suggested that chronic inflammation may play a critical role in endometrial carcinogenesis.MethodsTo investigate this hypothesis, a two-stage study was carried out to evaluate single-nu…