Liu H

Gynecological cancers present significant therapeutic challenges due to heterogeneity, drug resistance, and the lack of precise diagnostic tools. Selenium (Se), an essential trace element with intrinsic anticancer activity, has emerged as a…

IntroductionIn this exploratory case-control study, we investigated the potential associations of pregnancy-associated plasma protein-A (PAPP-A), β-human chorionic gonadotrophin (β-HCG), vascular endothelial growth factor (VEGF), and leukem…

Female reproductive disorders influence women's physical and mental well-being, and the sustainability of the family. However, it is unclear whether lifestyle factors, including sedentary behaviors and physical activity, could impact them. …

Background/aimsAge-related macular degeneration (AMD) is a progressive degenerative disease of the retinal macula associated with aging, which is one of the main causes of vision loss in the elderly. This research aims to investigate the me…

BackgroundOvarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management re…

BackgroundUnexplained recurrent spontaneous abortion (URSA) poses a significant clinical challenge with an elusive pathogenesis. FABP4 is crucial for lipid homeostasis and placental development, but its specific role and regulatory mechanis…

BACKGROUND: Endometriosis, a common chronic gynecological disorder, involves cellular autophagy and inflammatory processes in its pathogenesis. However, the specific regulatory mechanisms of autophagy and inflammation in endometriosis remai…

Accessory cavitated uterine malformation is a rare congenital anomaly of Müllerian duct development that typically affects younger women of reproductive age. The most common symptoms include chronic cyclic pelvic pain and severe dysmenorrhe…

BackgroundLung cancer is a prevalent form of cancer worldwide, presenting a substantial risk to human well-being. Lung cancer is classified into two main types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). The advan…

PurposeARID1A, encoding a component of the switch/sucrose nonfermentable complex, is frequently mutated in urothelial carcinoma. However, its specific impacts on clinical outcomes and CD8+ T-cell functions in urothelial carcinoma remain poo…

Repeated implantation failure (RIF) presents a significant challenge to in vitro fertilization (IVF), and abnormalities in the endometrium often play a crucial role in RIF. To enhance and deepen our understanding of tissue context in the en…

BackgroundOrganochlorine pesticides (OCPs) are extensively dispersed throughout the environment, which potentially have harmful impacts on the female reproductive system. Therefore, the purpose of this study was to clarify the association b…

This study aims to explore the association between stress coping and primary dysmenorrhea among Chinese female adolescent students. A two-step random, stratified, cluster sampling method was employed to assess the health status of female ad…

BACKGROUND: Uterine fibroids and endometriosis are common benign gynecological diseases affecting the health of women of childbearing age, characterized by high incidence and recurrence rates. Despite the increasing global emphasis on women…

BACKGROUND: Bowel endometriosis (BE) is a complex condition that can present with diverse clinical manifestations, impacting the quality of life for affected individuals. This retrospective case series aimed to investigate the clinical char…

BACKGROUND: The causal bridge from environmental exposure to endometriosis (Ems) biology remains incompletely defined. Di(2-ethylhexyl) phthalate (DEHP) is repeatedly implicated in elevated Ems risk, yet actionable molecular anchors linking…

Extra-pelvic endometriosis always presents complex diagnostic challenges due to its non-specific symptoms. We describe a rare case of coexisting iatrogenic abdominal wall endometriosis (AWE) and thoracic endometriosis (TE) in a 33-year-old …

Therapeutics for thin endometrium (TE) have emerged, with autologous platelet-rich plasma (PRP) therapy gaining significant attention. In the present study, ten eligible TE patients were recruited for PRP infusion. Endometrial tissue biopsi…

BackgroundWith the development of society, fertility seems to have become a public health issue in East Asian countries. At present, there is insufficient attention to infertility, especially male infertility. Understanding the burden and t…

ObjectiveThe study aimed to explore the effects of platelet-rich plasma (PRP) gel on vaginal microecology and stump healing, as well as its underlying mechanism.MethodsFrom December 2022 to August 2024, 100 patients who underwent laparoscop…

OBJECTIVE: With the rising frequency and earlier onset of endometrial cancer (EC), improved surgical skills have emerged as a priority. The objective of this study was to determine the effectiveness and safety of transumbilical laparoendosc…

Fungal biofilms, as self-produced extracellular polymeric substances that resist antifungal agents and immune defense, represent a major cause of treatment failure and recurrent infections. Therefore, it is of great importance to eradicate …

AIMS: The present study aimed to examine the roles of circRNA-circSMAD2 and its regulatory mechanisms in endometriosis (EMs). BACKGROUND: Evidence has confirmed that circRNAs play multiple roles in regulating the occurrence and development…

Transient receptor potential melastatin M3 (TRPM3) channels have been recognized as a pain transducer in dorsal root ganglion (DRG) neurons in recent years. TRPM3 activation initiates neurogenic inflammation and is required for the developm…