Amanda Rui En Woo

No ORCID on file · 2 papers in corpus

lab-animal 2022

Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

BMC biology ·doi:10.1186/s12915-022-01410-3

BACKGROUND: Progesterone receptor (PGR) is a master regulator of uterine function through antagonistic and synergistic interplays with oestrogen receptors. PGR action is primarily mediated by activation functions AF1 and AF2, but their phys…

lab-animal 2014

Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor

The Journal of biological chemistry ·doi:10.1074/jbc.m113.522839

Progesterone receptor (PR) exists in two isoforms, PRA and PRB, and both contain activation functions AF-1 and AF-2. It is believed that AF-1 is primarily responsible for the ligand-independent activity, whereas AF-2 mediates ligand-depende…