Yanagisawa H

ORCID: 0000-0002-7576-9186 · 2 papers in corpus · active 2011-2013
2013
Dysregulation of protease and protease inhibitors in a mouse model of human pelvic organ prolapse.
PloS one ·doi:10.1371/journal.pone.0056376

Mice deficient for the fibulin-5 gene (Fbln5(-/-)) develop pelvic organ prolapse (POP) due to compromised elastic fibers and upregulation of matrix metalloprotease (MMP)-9. Here, we used casein zymography, inhibitor profiling, affinity pull…

2011
Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans.
The Journal of clinical investigation ·doi:10.1172/jci45636

Pelvic organ prolapse (POP) is a common condition affecting almost half of women over the age of 50. The molecular and cellular mechanisms underlying this condition, however, remain poorly understood. Here we have reported that fibulin-5, a…