James L. Wittliff

article 1986

Estrogen and progestin receptors in human uterus: reference ranges of clinical conditions.

Clinical physiology and biochemistry

Estrogen receptor (ER) and progestin receptor (PR) levels and their respective dissociation constants (Kd) were determined by titration assay and Scatchard analyses in 319 human uteri. Levels of receptors were neither age nor uterine weight…

article 1985

Cytochrome P-450 activity in human leiomyoma and normal myometrium

·doi:10.1016/0002-9378(85)90471-5

Variations in cytochrome P-450 levels may influence the responsiveness of uterine and breast tissue as well as carcinomas to endocrine therapy and may be of particular importance with agents such as tamoxifen (Nolvadex) where hydroxylation …

article 1985

Evaluation of danazol influence upon the uterus using scanning electron microscopic morphometric and biochemical analyses.

A study using a Sprague-Dawley rat model was designed to correlate morphologic and intracellular steroid receptor alteration with danazol therapy. One uterine horn was removed for cytoplasmic estrogen receptor analysis following four to eig…

article 1983

Influence of danazol on cytoplasmic and nuclear estrogen binding capacity in the uterus

·doi:10.1016/s0002-9378(16)32226-8

Sprague-Dawley rats with estrous cycles were exposed to danazol (Danocrine) at a single dose of 10 mg/kg for either 6 or 24 hours, or daily until a pattern of no cycles (6 days) was noted on vaginal smears. The animals were individually hou…