Nobuhisa Yoshikawa

ORCID: 0000-0001-8662-9421 · 6 papers in corpus
article 2022
Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis
·doi:10.1016/j.matbio.2022.03.003

Ovarian cancer (OvCa), a lethal gynecological malignancy, disseminates to the peritoneum. Mesothelial cells (MCs) act as barriers in the abdominal cavity, preventing the adhesion of cancer cells. However, in patients with OvCa, they are tra…

2020
The impact of systematic retroperitoneal lymphadenectomy on long-term oncologic outcome of women with advanced ovarian clear-cell carcinoma.
Journal of gynecologic oncology ·doi:10.3802/jgo.2020.31.e47

ObjectiveThe impact of systematic retroperitoneal lymphadenectomy (SRL) remains controversial in patients with advanced ovarian clear-cell carcinoma (CCC) who are optimally debulked.MethodsBetween 1986 and 2017, a total of 3,227 women with …

2020
The Preoperative Prognostic Nutritional Index for the Prediction of Outcomes in Patients with Early-Stage Ovarian Clear Cell Carcinoma.
Scientific reports ·doi:10.1038/s41598-020-64171-5

The prognostic nutritional index (PNI), which reflects preoperative malnutrition, is useful for predicting the incidence of postoperative complications and has been reported in recent years to predict the long-term prognosis of various mali…

review 2019
Endometriosis and cancer
Free radical biology & medicine ·doi:10.1016/j.freeradbiomed.2018.12.015

Endometriosis, characterized by the presence of extra-uterine endometrium, is a common gynecologic disorder in reproductive-age women. Although the detailed molecular mechanism of etiology remains unelucidated, recent studies have gradually…

2019
Fertility-Sparing surgery for young women with ovarian endometrioid carcinoma: a multicenteric comparative study using inverse probability of treatment weighting.
European journal of obstetrics & gynecology and reproductive biology: X ·doi:10.1016/j.eurox.2019.100071

IntroductionThe aim of this study was to evaluate the oncologic outcome of women with stage I ovarian endometrioid carcinoma (EC) who underwent fertility-sparing surgery (FSS).Materials and nethodsBetween 1986 and 2017, a total of 3227 pati…

article 2017
A novel mechanism of neovascularization in peritoneal dissemination via cancer-associated mesothelial cells affected by TGF-β derived from ovarian cancer
·doi:10.3892/or.2017.6104

Epithelial ovarian cancer (EOC) is believed to cause peritoneum dissemination through microenvironmental cell‑to-cell communication between the tumor and mesothelium, leading to the further acquisition of progressive and metastatic potentia…