Smith AM

ORCID: 0000-0002-8716-6745 · 3 papers in corpus
article 2026
Inflammation, Estrogen, and Matrix Remodeling in Female Reproductive Health: From Crosstalk Mechanisms to Translational Diagnostics
Biology of reproduction ·doi:10.1093/biolre/ioag156

The female reproductive system is a hormonally driven, immune-active, and structurally dynamic system in which estrogen signaling, inflammation, and extracellular matrix (ECM) remodeling interact to support essential reproductive processes.…

2025
C1 esterase inhibitor (C1-INH) response as a supportive diagnostic criterion for patients with suspected hereditary angioedema with normal C1-INH.
The World Allergy Organization journal ·doi:10.1016/j.waojou.2025.101125

Diagnosis of hereditary angioedema (HAE) with normal C1INH level (HAE-nl-C1INH) is based on several criteria, including either an associated genetic variant identified or family history of recurrent angioedema plus lack of high-dose antihis…

2021
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2022760118

DNA hypomethylation is a feature of epidermal cells from aged and sun-exposed skin, but the mechanisms responsible for this methylation loss are not known. Dnmt3a is the dominant de novo DNA methyltransferase in the skin; while epidermal Dn…