Aravind L

ORCID: 0000-0003-0771-253X · 2 papers in corpus · active 2013-2021
2021
GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.
Science advances ·doi:10.1126/sciadv.abe2470

What covalent modifications control the temporal ubiquitination of ERα and hence the duration of its transcriptional activity remain poorly understood. We show that GREB1, an ERα-inducible enzyme, catalyzes O-GlcNAcylation of ERα at residue…

2013
Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA.
Nucleic acids research ·doi:10.1093/nar/gkt573

Discovery of the TET/JBP family of dioxygenases that modify bases in DNA has sparked considerable interest in novel DNA base modifications and their biological roles. Using sensitive sequence and structure analyses combined with contextual …