Paola Bargagna-Mohan

lab-animal 2007

The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin

Chemistry & biology ·doi:10.1016/j.chembiol.2007.04.010

The natural product withaferin A (WFA) exhibits antitumor and antiangiogenesis activity in vivo, which results from this drug's potent growth inhibitory activities. Here, we show that WFA binds to the intermediate filament (IF) protein, vim…

lab-animal 2006

Development of withaferin A analogs as probes of angiogenesis

Bioorganic & medicinal chemistry letters ·doi:10.1016/j.bmcl.2006.02.039

The natural product withaferin A (WFA) is a potent angiogenesis inhibitor and it targets the ubiquitin-proteasome pathway in vascular endothelial cells. We generated a biotinylated affinity analog WFA-LC(2)B for use as a probe to study angi…

lab-animal 2005

Use of PROTACS as molecular probes of angiogenesis

Bioorganic & medicinal chemistry letters ·doi:10.1016/j.bmcl.2005.04.008

Small molecules designed to specifically activate or inactivate protein functions have been useful to study biological processes. PROTACS are small molecule chimera which comprise a ligand and a peptide recognition motif for an E3 ligase. T…