Sakaue S

ORCID: 0000-0003-3618-9717 · 2 papers in corpus

2024

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.

Nature genetics ·doi:10.1038/s41588-024-01682-1

Translating genome-wide association study (GWAS) loci into causal variants and genes requires accurate cell-type-specific enhancer-gene maps from disease-relevant tissues. Building enhancer-gene maps is essential but challenging with curren…

2020

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.

Nature genetics ·doi:10.1038/s41588-020-0640-3

The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the East Asian population, we conducted a genome-wide association study (GWAS) with 212,453 Japanese individuals …