Janusz Witowski

ORCID: 0000-0002-1093-6027 · 2 papers in corpus

lab-animal 2024

Effect of cellular senescence on the response of human peritoneal mesothelial cells to TGF-β

Scientific reports ·doi:10.1038/s41598-024-63250-1

Transforming growth factor β (TGF-β) is implicated in both mesothelial-to-mesenchymal transition (MMT) and cellular senescence of human peritoneal mesothelial cells (HPMCs). We previously showed that senescent HPMCs could spontaneously acqu…

lab-animal 2021

Autoantibodies from Patients with Scleroderma Renal Crisis Promote PAR-1 Receptor Activation and IL-6 Production in Endothelial Cells

International journal of molecular sciences ·doi:10.3390/ijms222111793

BACKGROUND: Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc). Autoantibodies (Abs) against endothelial cell antigens have been implicated in SSc and SRC. However, their detailed roles remain poor…