White LD

No ORCID on file · 3 papers in corpus · active 2009-2010

Condition tags

  • infertility 1
2010
Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling.
Biology of reproduction ·doi:10.1095/biolreprod.109.080259

Conditional ablation of Indian hedgehog (Ihh) in the murine uterus results in mice that are sterile because of defects in embryo implantation. We performed microarray analysis on these mice at the time point at which the Ihh target genes ar…

2010
Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse.
Biology of reproduction ·doi:10.1095/biolreprod.109.081513

Previous work has identified Indian hedgehog (Ihh) as a major mediator of progesterone signaling during embryo implantation. Ihh acts through its downstream effector smoothened (Smo) to activate the GLI family of transcription factors. In o…

2009
Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.0903632106

Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects. An imbalance caused by increased E2 action and/or decreased P4 action can result in abnormal endometrial proliferation and, ultimately, endometri…