Zhao Y

BackgroundSurvival rates for ovarian cancer drop sharply at late-stages due to late diagnosis. Although PARP inhibitors are effective in homologous recombination-deficient (HRD) tumors, their efficacy in homologous recombination (HR)-profic…

Esophageal squamous cell carcinoma (ESCC) is a significantly fatal gastrointestinal malignancy worldwide, with complex proteomic remodeling during its onset and progression. Despite advancements in existing multimodal therapy regimens, the …

Bone is highly innervated, and its regeneration is significantly nerve-dependent. Extensive evidence suggests that the nervous system plays an active role in bone metabolism and development by modulating osteoblast and osteoclast activity. …

Female reproductive disorders present significant challenges worldwide. Transfer RNA-derived small RNAs (tsRNAs), a structurally diverse class of non-coding RNAs mainly comprising tRNA halves (tiRNAs) and tRNA-derived fragments (tRFs), have…

Long non-coding RNA Urothelial carcinoma-associated 1 (UCA1) is a pivotal regulator in the progression of endometriosis (EMs), yet its mechanistic role remains elusive. This study identified UCA1 as a factor promoting glycolysis through bio…

BackgroundInfertility poses a significant health challenge for reproductive-aged women globally and could be shaped by both genetic risks and lifestyle factors. Existing studies predominantly focus on individual lifestyle components, while …

ObjectiveOur study aims to establish and validate a diagnostic scoring system for distinguishing malignant cystic ovarian tumors (MCOTs) from benign cystic ovarian tumors (BCOTs).MethodsThe study population was sourced from two independent …

BACKGROUND: Adenomyosis, a common gynecological disorder in women of reproductive age, is characterized by endometrial invasion into the myometrium, leading to uterine enlargement and smooth muscle hypertrophy. Typical clinical symptoms inc…

In the treatment of ulcerative colitis (UC), persistent inflammatory activity increases the risk of recurrence and poor prognosis. Probe-based confocal laser endomicroscopy (pCLE) can accurately assess the UC inflammation than conventional …

Testosterone is commonly measured using immunoassays in clinical practice; however, these methods are subject to analytical interference in both men and women. In women, due to physiologically lower testosterone levels, even modest elevatio…

Abstract Background: Ovarian sex cord-stromal tumors are rare neoplasms originating from the sex cords and stromal tissue of the ovary, with extraovarian occurrences being even rarer in clinical settings. In this report, we describe a case…

BACKGROUND: Endometriosis is a chronic inflammatory disorder affecting reproductive-aged women. The Dietary Inflammatory Index (DII), a measure of diet-related inflammation, has been implicated in various inflammatory diseases, but its role…

ObjectiveTo investigate the relationship between protein-rich foods, various nutritional supplements, and age of natural menopause and its symptoms.MethodsThis study was a large-scale cross-sectional survey. A multi-stage stratified random …

The aim of this study is to investigate the mechanism of action and correlation between transforming growth factor beta 1 (TGF-β1) and β-catenin in pelvic organ prolapse (POP). The study compared vaginal wall tissues from two groups: 20 pat…

Women's reproductive health plays a pivotal role in both longevity and the aging process. We conduct Mendelian randomization (MR) and observational analyses to investigate these relationships. Univariate MR analyses reveal that older age at…

BackgroundThe administration of exogenous gonadotropins (Gn) to elicit multi-follicular development for controlled ovarian stimulation (COS) represents a pivotal component of assisted reproductive technology (ART). Presently, the exogenous …

This study investigated differences in reproductive outcomes and vaginal microbiota profiles between two endometrial preparation protocols-letrozole (LE) combined with human menopausal gonadotropin (HMG) and hormone replacement therapy (HRT…

IN BRIEF: There is no ideal animal model of adenomyosis, which reflects the imperfect understanding of complex human pathogenesis. In this study, we successfully induced adenomyosis in a mouse model via sharp-blunt trauma, which more closel…

PURPOSE: Endometriosis (EMS) is a chronic gynecological disorder with unclear pathogenesis. While the vaginal and gut microbiomes are known to influence EMS, few studies have analyzed both microbiomes integrally. This study aims to characte…

Yiming Zhao,1,2,* Xinyu Hu,1,* Chunyan Li,2 Jing Huang,3 Ke Guo,4 Qiong Pan,1 Zheng Yu2 1Department of Obstetrics and Gynecology, the Third Xiangya Hospital of Central South University, Changsha, People’s Republic of China; 2Human M…

[This corrects the article DOI: 10.3389/fgene.2025.1614573.].

ObjectiveTo develop and validate a diagnostic nomogram model for predicting atypical endometrial hyperplasia (AEH) and endometrial carcinoma (EC) in women aged 40-60 years with abnormal uterine bleeding (AUB), incorporating detailed bleedin…

BackgroundInfertility has become a global health concern, especially as the aging population continues to grow. Previous studies suggest that gut microbiota plays a crucial role in female reproductive health. This study aimed to investigate…