Narendra P. Singh

lab-animal 2023

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces multigenerational alterations in the expression of microRNA in the thymus through epigenetic modifications

PNAS nexus ·doi:10.1093/pnasnexus/pgac290

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a potent AhR ligand, is an environmental contaminant that is known for mediating toxicity across generations. However, whether TCDD can induce multigenerational changes in the expression of microR…

lab-animal 2023

Estrobolome dysregulation is associated with altered immunometabolism in a mouse model of endometriosis

Frontiers in endocrinology ·doi:10.3389/fendo.2023.1261781

INTRODUCTION: Endometriosis is a painful disease that affects around 5% of women of reproductive age. In endometriosis, ectopic endometrial cells or seeded endometrial debris grow in abnormal locations including the peritoneal cavity. Commo…

lab-animal 2019

AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes

Journal of immunology (Baltimore, Md. : 1950) ·doi:10.4049/jimmunol.1900291

The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant, is a potent ligand for aryl hydrocarbon receptor (AhR). In the current study, we made an exciting observation that naive C57BL/6 mice that were exposed i…