Susan J. Fisher — Endo Lab

2025

Multi-omics-based mapping of decidualization resistance in patients with a history of severe preeclampsia.

Nature medicine ·doi:10.1038/s41591-024-03407-7

Endometrial decidualization resistance (DR) is implicated in various gynecological and obstetric conditions. Here, using a multi-omic strategy, we unraveled the cellular and molecular characteristics of DR in patients who have suffered seve…

review 2025

Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence

npj women's health ·doi:10.1038/s44294-024-00052-w

Endometriosis is an enigmatic disease whose diagnosis and management are being transformed through innovative surgical, molecular, and computational technologies. Integrating single-cell and other omic disease data with clinical and surgica…

2017

Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology.

Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1706546114

In preeclampsia (PE), cytotrophoblast (CTB) invasion of the uterus and spiral arteries is often shallow. Thus, the placenta's role has been a focus. In this study, we tested the hypothesis that decidual defects are an important determinant …

article 2014

Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals

Journal of proteomics ·doi:10.1016/j.jprot.2014.09.015

Endometriosis, ectopic growth of the uterine lining (endometrium), which affects 6-11% of reproductive age women, is associated with pelvic pain and infertility. We investigated the peritoneal fluid (PF), urine and omental fat (OF) proteome…