Sandrine Marchais‐Oberwinkler

ORCID: 0000-0001-9941-7233 · 1 paper in corpus

article 2012

Lead Optimization of 17β-HSD1 Inhibitors of the (Hydroxyphenyl)naphthol Sulfonamide Type for the Treatment of Endometriosis

Journal of medicinal chemistry ·doi:10.1021/jm201735j

The reduction of estrone to estradiol, the most potent estrogen in human, is catalyzed by 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1). A promising approach for the treatment of estrogen-dependent diseases is the reduction of intracel…