Lambertus van den Heuvel

KEY POINTS: Apolipoprotein L1 variants were transported to the plasma membrane via actin filaments, where they exhibited distinct dynamics. Apolipoprotein L1 was functionally expressed at the plasma membrane and formed a voltage-dependent n…

Fifteen years have elapsed since the publication of the seminal work establishing the association between risk variants in the Apolipoprotein L1 (APOL1) gene and kidney disease in individuals of African ancestry. During this period, substan…