Junnan Fang

No ORCID on file · 4 papers in corpus
lab-animal 2026
Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.202601614r

Ovarian senescence is accompanied by inflammatory responses, yet the underlying mechanism remains incompletely elucidated. In this study, transcriptome sequencing was performed on ovarian granulosa cells from advanced-age patients and norma…

lab-animal 2026
NR4A1-Driven Granulosa Cell Ferroptosis Contributes to Obesity-Related Ovarian Dysfunction and Metformin-Mediated Ovarian Protection
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.202603415r

Obesity triggers ovarian dysfunction and female infertility accompanied by granulosa cell damage. Ferroptosis, iron-dependent lipid peroxidation-mediated cell death, participates in multiple reproductive diseases, yet the molecular cascade …

other 2025
Human oocyte zona pellucida abnormalities: evaluation of clinical impact for different zona pellucida abnormalities and role of using assisted hatching
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-024-03306-3

BACKGROUND: Zona pellucida (ZP) plays an important role in oocyte development and fertilisation, as well as in early embryo development. However, there is currently no exploration of systematic categorising and clinical treatment measures f…

observational 2024
Exploring key embryonic developmental morphokinetic parameters that affect clinical outcomes during the PGT cycle using time-lapse monitoring systems
BMC pregnancy and childbirth ·doi:10.1186/s12884-024-07080-z

RESEARCH QUESTION: Is it possible to predict blastocyst quality, embryo chromosomal ploidy, and clinical pregnancy outcome after single embryo transfer from embryo developmental morphokinetic parameters? DESIGN: The morphokinetic parameter…