Melinda S. Yates — Endo Lab

2025

Photodynamic priming overcomes platinum resistance from short-term exposure to select perfluoroalkyl substances in endometrial cancer cell lines.

Photochemistry and photobiology ·doi:10.1111/php.14073

First-line treatment for advanced-stage or recurrent endometrial cancer consists of platinum- and taxane-based chemotherapy, to which many patients will develop resistance. Determining the factors that contribute to platinum resistance and …

article 2024

Spatial transcriptomics identifies unique loss of immunosurveillance in endometrial cancers of women with severe obesity

·doi:10.1016/j.ygyno.2024.07.031

2024

Uterine-Conserving Treatment Options for Atypical Endometrial Hyperplasia and Early Endometrial Cancer.

Current oncology reports ·doi:10.1007/s11912-024-01603-9

Purpose of reviewThis review aims to synthesize available literature on uterine-conserving treatment options for atypical endometrial hyperplasia and grade 1 endometrial carcinoma while highlighting remaining unanswered questions.Recent fin…

other 2015

Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma

Journal of Clinical Oncology ·doi:10.1200/JCO.2014.58.3401

PURPOSE: The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endometrial cancer (EC). Hormonal manipulation leads to response in some patients with EC, but resistance derived from PI3K pathway activation has been docum…

2015

Salpingectomy as a means to reduce ovarian cancer risk.

Cancer prevention research (Philadelphia, Pa.) ·doi:10.1158/1940-6207.capr-14-0293

Bilateral salpingo-oophorectomy (BSO) has become the standard-of-care for risk reduction in women at hereditary risk of ovarian cancer. Although this procedure significantly decreases both the incidence of and mortality from ovarian cancer,…