Francesca Cencetti

ORCID: 0000-0003-4351-2965 · 4 papers in corpus
lab-animal 2024
Sphingosine 1-phosphate signaling axis mediates neuropeptide S-induced invasive phenotype of endometriotic cells
The FEBS journal ·doi:10.1111/febs.17071

Endometriosis is a chronic gynecological syndrome characterized by endometrial cell invasion of the extra-uterine milieu, pelvic pain and infertility. Treatment relies on either symptomatic drugs or hormonal therapies, even though the mecha…

lab-animal 2023
Sphingosine 1-phosphate elicits a ROS-mediated proinflammatory response in human endometrial stromal cells via ERK5 activation
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.202300323r

Endometriosis is a chronic gynecological disease affecting ~10% women in the reproductive age characterized by the growth of endometrial glands and stroma outside the uterine cavity. The inflammatory process has a key role in the initiation…

other 2021
Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect
Fertility and sterility ·doi:10.1016/j.fertnstert.2020.12.022

OBJECTIVE: To explore the link between sphingosine 1-phosphate (S1P) signaling and leiomyoma and the possible S1P cross-talk with the fibrotic effect of activin A. DESIGN: Case-control laboratory study. SETTING: University institute and u…

other 2020
Sphingosine 1-phosphate receptors are dysregulated in endometriosis: possible implication in transforming growth factor β-induced fibrosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2020.08.012

OBJECTIVE: To study the molecular mechanisms involved in the appearance of the fibrotic trait in endometriosis by investigating whether the signaling pathway of the bioactive sphingolipid sphingosine 1-phosphate (S1P) was altered in endomet…