Demenais F — Endo Lab

2020

Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma.

Nature communications ·doi:10.1038/s41467-020-16590-1

Genome-wide association studies (GWAS) have identified ~20 melanoma susceptibility loci, most of which are not functionally characterized. Here we report an approach integrating massively-parallel reporter assays (MPRA) with cell-type-speci…

2016

Genes Involved in Interleukin-1 Receptor Type II Activities Are Associated With Asthmatic Phenotypes.

Allergy, asthma & immunology research ·doi:10.4168/aair.2016.8.5.466

PurposeInterleukin-1 (IL-1) plays a key role in inflammation and immunity and its decoy receptor, IL-1R2, has been implicated in transcriptomic and genetic studies of asthma.MethodsTwo large asthma family collections, the French-Canadian Sa…

2015

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.

Nature genetics ·doi:10.1038/ng.3373

Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis…

2014

The effect on melanoma risk of genes previously associated with telomere length.

Journal of the National Cancer Institute ·doi:10.1093/jnci/dju267

Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 111…

2011

Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3.

Nature genetics ·doi:10.1038/ng.958

We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and 4,387 control individuals. In this discovery phase, we confirm several previously characterized melanoma-associ…